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These point mutations are clustered around 2 hotspots mapped to amino acids at positions 641 to 649 (hotspot 1) and 1,345 to 1,365 (hotspot 2). Point mutations that alter echinocandin sensitivity decrease enzyme velocity, V max, but not the binding affinity, K m, of the drug for Fks enzyme. Serine is frequently substituted with phenylalanine ... lampu4d login